My group once crossed Aberrant with Adventure - which, while belonging to the same universe, had
completely different power scales. But I wanted to play a Batman-esque, pulp hero type, instead of the godlike characters Aberrant had, so the Storyteller allowed it. While my character had definite limitations when it came to dishing out or taking damage, it was still pretty fun to do.
Especially when I kept outclassing one of the novas whenever he tried to do the same things, much to that player's frustration.