Maybe, probably.
I feel like if he doesn't have unlimited energy he'd struggle to deal with the combo of IH and Wheel without burning out of energy. Divine Bulls are hard to deal with, although even if he's not at all Herc, I gues he technically has monsterslaying stuff to him so he can deal with them. Not like it'll be a casual they just die thing however.
IH seems like it works really well against him since its decent mooks that'll bleed him dry of energy and he's a ridiculous gas guzzler.
So really I see a lot of ways for Iskander to win.